| Item Type | Name |
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Concept
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Models, Molecular
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Academic Article
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Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin.
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Academic Article
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Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
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Academic Article
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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
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Academic Article
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Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis.
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Academic Article
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Modular total chemical synthesis of a human immunodeficiency virus type 1 protease.
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Academic Article
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Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors.
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Academic Article
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Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.
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Academic Article
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Catalytic mechanism and regulation of mammalian adenylyl cyclases.
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Academic Article
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Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase.
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Academic Article
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Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
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Academic Article
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Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin.
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Academic Article
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Conversion of forskolin-insensitive to forskolin-sensitive (mouse-type IX) adenylyl cyclase.
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Academic Article
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Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site.
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Academic Article
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Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.
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Academic Article
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Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
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Academic Article
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Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.
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Academic Article
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A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step.
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Academic Article
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Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.
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Academic Article
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Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme.
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Academic Article
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Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
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Academic Article
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The adenylyl cyclase activity of anthrax edema factor.
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Academic Article
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Three discrete regions of mammalian adenylyl cyclase form a site for Gsalpha activation.
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Academic Article
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Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme.
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Academic Article
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Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation.
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Academic Article
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Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
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Academic Article
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Molecular basis of substrate recognition and degradation by human presequence protease.
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Academic Article
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Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
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Academic Article
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Catalytic Mechanism of Amyloid-ß Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller-Plesset Second Order Perturbation Theory Calculation.
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Academic Article
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Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
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Academic Article
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Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor.
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Academic Article
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Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
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Academic Article
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Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.
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Academic Article
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Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor.
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Academic Article
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Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates.
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Academic Article
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Calcium dependence of the interaction between calmodulin and anthrax edema factor.
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Academic Article
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Pseudomonas aeruginosa exoenzyme Y directly bundles actin filaments.
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Academic Article
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Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states.
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